Dementia is leading cause of death in England & Wales
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perdido
- Posts: 1528
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Good find Flash.
Here's my oversimplified understanding of this article.
Gingipains seem to be key in these studies. So what causes gingipains?
They are byproducts of gingivalis and work to inhibit the function of cytokines
(the stuff that controls the basic activities of cells) and can prevent cells from joining the fight against infections.
Why is this important?
Preventing cells from joining the defense of the body allows infection to persist and spread.
How is this specifically related to alzheimers?
Continued infection creates excessive byproducts of the infection which accumulate in the brain.
In the past, these extra protein byproduct accumulations have been suspected of being the cause
of alzheimers but Flash's reference is instead focusing on the cause of these
byproducts(p.gingivalis) as being the link to alzheimers, not the protein byproducts created by the infection as originally thought.
In the mice study group the gingivalis infection has been orally introduced to mice that are pre-disposed to contracting alzheimers.
At various intervals the mice brains are analyzed and they are seeing gingivalis infection in the brain.
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These studies are looking for a way to control gingipains and find out if that will prevent alzheimers and help those that have alzheimers improve.
If these studies are relevant to alzheimers maybe they can find a way to block those gingipains from inhibiting or eliminate the gingivalis infection.
As far as aluminum, it is proven to be damaging to the central nervous system, all alzheimers studies have been guesswork as to actual cause.
Who knows what may be found as contributing factors of contracting alzheimers, a combination of things most likely.
Or maybe not?
.
Here's my oversimplified understanding of this article.
Gingipains seem to be key in these studies. So what causes gingipains?
They are byproducts of gingivalis and work to inhibit the function of cytokines
(the stuff that controls the basic activities of cells) and can prevent cells from joining the fight against infections.
Why is this important?
Preventing cells from joining the defense of the body allows infection to persist and spread.
How is this specifically related to alzheimers?
Continued infection creates excessive byproducts of the infection which accumulate in the brain.
In the past, these extra protein byproduct accumulations have been suspected of being the cause
of alzheimers but Flash's reference is instead focusing on the cause of these
byproducts(p.gingivalis) as being the link to alzheimers, not the protein byproducts created by the infection as originally thought.
In the mice study group the gingivalis infection has been orally introduced to mice that are pre-disposed to contracting alzheimers.
At various intervals the mice brains are analyzed and they are seeing gingivalis infection in the brain.
-----
These studies are looking for a way to control gingipains and find out if that will prevent alzheimers and help those that have alzheimers improve.
If these studies are relevant to alzheimers maybe they can find a way to block those gingipains from inhibiting or eliminate the gingivalis infection.
As far as aluminum, it is proven to be damaging to the central nervous system, all alzheimers studies have been guesswork as to actual cause.
Who knows what may be found as contributing factors of contracting alzheimers, a combination of things most likely.
Or maybe not?
.
A few years ago a rather large study was done on the brains of deceased Alzheimer's patients. Protein 'crystals' or 'knots' in large number were found. When compared to non-Alzhheimer's patients of comparable age, normal aging brains get some of this, but Alzheimer's patients get orders of magnitude more.
There was great debate about these knots or crystals, but it boiled down to some form of
a.) polymerization of a small protein or protein family, or
b.) a defective/substituted protein catalyst that caused complex proteins to malform.
I find the cytokines a welcomed third alternative. And it appears that oral health is indeed a pathway.
Good stuff here, eventually.
Regards
8Geee
There was great debate about these knots or crystals, but it boiled down to some form of
a.) polymerization of a small protein or protein family, or
b.) a defective/substituted protein catalyst that caused complex proteins to malform.
I find the cytokines a welcomed third alternative. And it appears that oral health is indeed a pathway.
Good stuff here, eventually.
Regards
8Geee
Linux user #498913 "Some people need to reimagine their thinking."
"Zuckerberg: a large city inhabited by mentally challenged people."
"Zuckerberg: a large city inhabited by mentally challenged people."
Good question. If you google Porphyromonas gingivalis, you will find that it definitely is linked to heart disease, some forms of arthritis, and infamous for it's ability to enter and infect a wide variey of cell structures, which also makes it hard to kill. As may be the case with Alzheimer, the secondary effect caused by antibodies seem to be as great a problem.
I may add that I recently cracked a tooth, which sadly have to be extracted one of the days this week. My dentist told me that cracked teeth was one of the real problem areas, as bacteria form in the crack in a very short time, and can be really dangerous, often leading to a heart attack. I guess the bacteria we discuss is the main problem.
I may add that I recently cracked a tooth, which sadly have to be extracted one of the days this week. My dentist told me that cracked teeth was one of the real problem areas, as bacteria form in the crack in a very short time, and can be really dangerous, often leading to a heart attack. I guess the bacteria we discuss is the main problem.
True freedom is a live Puppy on a multisession CD/DVD.
But wait, there's more. The hits just keep on coming:
Treating high blood pressure could reduce risk of memory issues
Treating high blood pressure could reduce risk of memory issues
By Dr. Tara Narula CBS News January 28, 2019
A new study finds lowering blood pressure could cut the risk of developing a brain disorder that can lead to Alzheimer's and other forms of dementia. One in three American adults have high blood pressure and only half have it under control.
The lead author of the study, Dr. Jeff Williamson of Wake Forest School of Medicine, called the findings a leap forward.
"For the first time in history we can say, in terms of blood pressure lowering treatment, what is good for your heart is also good for your brain," Williamson said.
The study looked at the effect of more intensive blood pressure control and risks of developing mild cognitive impairment. That's when people develop problems with thinking and planning, but can still do everyday tasks. It can be a gateway to dementia.
Researchers followed more than 9,000 people age 50 or older for around three years and found lowering blood pressure more aggressively — getting the systolic blood pressure number below 120 — led to a 19 percent decrease in mild cognitive impairment compared to a less aggressive treatment with a number of 140.
About 75 percent of people over 65 have high blood pressure.
One patient, 63-year-old Don Penny, a commercial photographer, has been on medication to treat his high blood pressure and heart disease for about three years. He is serious about keeping those numbers low.
"My blood pressure is at a very manageable one, 120 over 70, over 75. So I'm in a good zone now for having blood pressure," Penny said.
Researchers didn't see the same effect for dementia, saying there were not enough cases in the study. Because of this, the Alzheimer's Association is going to help fund the study for another two years. This gives doctors something tangible to discuss with patients who are concerned about changes in mental function.
© 2019 CBS Interactive Inc. All Rights Reserved.
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ITSMERSH
There's just another interesting result of a European wide research published a few days ago in Germany, though can't find the link atm.One in three American adults have high blood pressure and only half have it under control.
It's being said that they found out that one in three adult lefties born later as the 1980s is exactly that stupid as the other two!
They also said the results clearly shows this being the main cause of many physical and psychic problems all over the world - but especially in so-called western countries.
The whole idea of intelligence is a failed theory. It was cooked up to excuse all kinds of crimes against nature and against humanity. Nobody has ever come up with a definition of intelligence that is widely accepted, so an IQ test purports to test something that has never been rigorously defined. It's mostly wishful thinking. We aspire to intelligence and we can't even say what that means.
Most definitions in science are basically restatements of how the thing in question is measured. This general rule does not apply to intelligence.
Most definitions in science are basically restatements of how the thing in question is measured. This general rule does not apply to intelligence.
We got some very bad pesticides here in France which are killing BILLIONS of bees. 
We dont even know what are the long run effects on men, who knows what we might find ?
And the president doesn't want to forbid those pesticides yet, he says "the farmers need pesticides to produce vegetables and fruits".
We dont even know what are the long run effects on men, who knows what we might find ?
And the president doesn't want to forbid those pesticides yet, he says "the farmers need pesticides to produce vegetables and fruits".